Journal
FEBS LETTERS
Volume 589, Issue 17, Pages 2224-2232Publisher
WILEY
DOI: 10.1016/j.febslet.2015.06.036
Keywords
Apoptosis; Cell proliferation; JAK2; Microarray miR-216a; Pancreatic cancer
Funding
- Special Fund for Public Welfare Industry of Health: the Translational Research of Early Diagnosis and Comprehensive Treatment in Pancreatic Cancer [201202007]
- Science and Technology Planning Project of Guangdong Province, China [20120314]
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This study was aimed to investigate miR-216a expression in pancreatic cancer and determine its effects on proliferation. miR-216a was found downregulated in pancreatic cancer tissues as compared to benign pancreatic lesions. JAK2 was identified as a miR-216a gene target. Further, in vivo treatment of PANC-1 tumors with miR-216a reduced JAK2 protein levels in the tumor and reduced tumor volume. In conclusion, miR-216a may function as a tumor suppressor regulating pancreatic cancer cells by targeting the JAK/STAT pathway. Further studies with a larger number of patient samples are necessary to fully explore the diagnostic and therapeutic potential of miR-216a for pancreatic cancer. (C) 2015 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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