Journal
AUTOIMMUNITY REVIEWS
Volume 17, Issue 9, Pages 906-911Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2018.03.014
Keywords
T-RM cells; Autoimmtme disease; Immune response; CD69; CD103
Categories
Funding
- National Natural Science Foundation of China [81522038, 81602767, 81430074]
- Programs of Science-Technology Commission of Hunan Province [2013F J4202]
- Natural Science Foundation of Hunan Province [2017JJ3453, 2017SK2042]
- Natural Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People's Republic of China
Ask authors/readers for more resources
The tissue-resident memory T (T-RM) cells constitute a newly identified subset of memory T cells which are non-circulating and they persist for long-term in epithelial barrier tissues, including skin, lung, gastrointestinal tract and reproductive tract, and in non-barrier tissues, including brain, kidney, pancreas and joint. These cells provide rapid on-site immune protection against previous exposed pathogens in peripheral tissues. There cells are transcriptionally, functionally and phenotypically distinguished from circulating effector memory T cells. In addition to their protective functions, increasing evidence reveals that autoreactive and/or aberrantly activated T-RM cells may be involved in the pathogenesis of autoimmune disorders such as psoriasis and, as recently reported, may contribute to vitiligo, autoimmune hepatitis and rheumatoid arthritis. Therefore, this review aims to summarize the current progress in the biology of T-RM cells, such as the newly identified T-RM markers, upstream regulators, and the functions of T-RM cells. We also discuss the contributions of T-RM cells to the development of autoimmunity to broaden our understanding of autoimmune diseases and to provide novel potential therapeutic strategies for these diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available