Journal
FEBS LETTERS
Volume 589, Issue 20, Pages 3126-3132Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.08.039
Keywords
Organelle; Mitochondria; Mitochondrial fission; Cytochrome oxidase (COX); Drp1
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [195900681, 26291044, 26111522, 15K18534]
- Grants-in-Aid for Scientific Research [26111522, 26291044, 26450127, 15K18534] Funding Source: KAKEN
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Mitochondria are dynamic organelles that alter their morphology in response to cellular signaling and differentiation through balanced fusion and fission. In this study, we found that the mitochondrial inner membrane ATPase ATAD3A interacted with ccdc56/MITRAC12/COA3, a subunit of the cytochrome oxidase (COX)-assembly complex. Overproduction of ccdc56 in HeLa cells resulted in fragmented mitochondrial morphology, while mitochondria were highly elongated in ccdc56-repressed cells by the defective recruitment of the fission factor Drp1. We also found that mild and chronic inhibition of COX led to mitochondrial elongation, as seen in ccdc56-repressed cells. These results indicate that ccdc56 positively regulates mitochondrial fission via regulation of COX activity and the mitochondrial recruitment of Drp1, and thus, suggest a novel relationship between COX assembly and mitochondrial morphology. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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