Journal
FEBS LETTERS
Volume 589, Issue 22, Pages 3461-3470Publisher
WILEY
DOI: 10.1016/j.febslet.2015.07.047
Keywords
Autophagy; Macroautophagy; Virus; Innate immunity; Adaptive immunity
Funding
- Millennium Institute on Immunology and Immunotherapy from Chile [P09/016-F]
- FONDECYT [1150862, 1070352, 1050979, 1040349, 1100926, 1110397, 1131012, 1140010, 1140011, 3140455]
- FONDEF [D11I1080]
- Biomedical Research Consortium [BMRC 13CTI-21526]
Ask authors/readers for more resources
Although identified in the 1960's, interest in autophagy has significantly increased in the past decade with notable research efforts oriented at understanding as to how this multi-protein complex operates and is regulated. Autophagy is commonly defined as a self-eating process evolved by eukaryotic cells to recycle senescent organelles and expired proteins, which is significantly increased during cellular stress responses. In addition, autophagy can also play important roles during human diseases, such as cancer, neurodegenerative and autoimmune disorders. Furthermore, novel findings suggest that autophagy contributes to the host defense against microbial infections. In this article, we review the role of macroautophagy in antiviral immune responses and discuss molecular mechanisms evolved by viral pathogens to evade this process. A role for autophagy as an effector mechanism used both, by innate and adaptive immunity is also discussed. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available