Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms17020202
Keywords
metal allergy; Ni; DTH; DC; T cell; TLR; TSLP
Funding
- Ministry of Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan [15K15676]
- Grants-in-Aid for Scientific Research [24689068, 25670798, 15K15676] Funding Source: KAKEN
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Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy.
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