Journal
RSC ADVANCES
Volume 6, Issue 32, Pages 26719-26724Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra03905g
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Funding
- POSCO
- Bio & Medical Technology Development Program of the National Research Foundation by the Korean government (MEST) [2012M3A9C6049791]
- Korean Health Technology R&D Project, Ministry of Health and Welfare, Korea [HI14C1658]
- National Research Foundation of Korea [2012M3A9C6049791] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Titanium (Ti) is one of the representative biocompatible metallic materials which has been widely exploited for various implants and bone replacements. Here, commercially pure Ti (CP Ti) was surface-modified with reduced graphene oxide (RGO) for accelerated bone regeneration and osseointegration. Nanoscale RGO coating on CP Ti was clearly confirmed by SEM, AFM, EDS, XPS, HR-TEM and EELS. In addition, pre-osteoblast cells cultured on RGO-CP Ti showed higher cell viability and cell attachment than those on CP Ti. After confirmation of the drug loading capability of RGO-CP Ti, osteogenic dexamethasone loaded RGO-CP Ti (Dex/RGO-CP Ti) was implanted on calvarial bone defects in rats. Synchrotron X-ray imaging successfully visualized more effective bone regeneration on Dex/RGO-CP Ti than CP Ti and RGO-CP Ti after 8 weeks.
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