Journal
FEBS LETTERS
Volume 589, Issue 15, Pages 1981-1987Publisher
WILEY
DOI: 10.1016/j.febslet.2015.04.061
Keywords
HOTAIR; miR-193a; c-KIT; Acute myeloid leukemia
Funding
- National Natural Science Foundation of China [81200350]
- Fund of Wenzhou Science and Technology Bureau [Y20130090, Y20130044]
Ask authors/readers for more resources
HOTAIR is significantly overexpressed in various cancers and facilitates tumor invasion and metastasis. However, whether HOTAIR plays oncogenic roles in acute myeloid leukemia (AML) is still unknown. Here, we report that HOTAIR expression was obviously increased in leukemic cell lines and primary AML blasts. Clinically, AML patients with higher HOTAIR predicted worse clinical outcome compared with those with lower HOTAIR. Importantly, HOTAIR knockdown by small hairpin RNA inhibited cell growth, induced apoptosis, and decreased number of colony formation. Finally, HOTAIR modulated c-KIT expression by competitively binding miR-193a. Collectively, our data suggest that HOTAIR plays an important oncogenic role in AML and might serve as a marker for AML prognosis and a potential target for therapeutic intervention. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available