Journal
FEBS JOURNAL
Volume 283, Issue 6, Pages 1004-1024Publisher
WILEY
DOI: 10.1111/febs.13573
Keywords
cancer; cancer biology; cell signaling; CIP2A; drug development; PP2A; protein phosphatases; SET; structural biology; tumor suppressors
Categories
Funding
- Howard Hughes Medical Institute (HHMI) Physician-Scientist Early Career Award
- Case Comprehensive Cancer Center Pilot Award
- NCI [R01CA181654]
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Protein phosphatase 2A (PP2A) is a serine/ threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post-translational modifications leading to its dysregulation in cancer. A final section will discuss the proteins and small molecules that modulate PP2A and how these might be used to target dysregulated forms of PP2A to treat cancers and other diseases.
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