Journal
FEBS JOURNAL
Volume 282, Issue 11, Pages 2076-2088Publisher
WILEY-BLACKWELL
DOI: 10.1111/febs.13249
Keywords
mitophagy; parkin; PINK1; ubiquitin; ubiquitination
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Funding
- Canadian Institutes of Health Research [MOP-125924]
- Fonds de la Recherche en Sante du Quebec
- la Societe Parkinson du Quebec
- NSERC CREATE Training Program in Bionanomachines
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Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway. Here, we review the structure of parkin and mechanisms of its autoinhibition and function as a ubiquitin ligase. We present a model for the recruitment and activation of parkin as a key regulatory step in the clearance of depolarized or damaged mitochondria by autophagy (mitophagy). We conclude with a brief overview of other functions of parkin and considerations for drug discovery in the mitochondrial quality control pathway.
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