Journal
FEBS JOURNAL
Volume 283, Issue 14, Pages 2577-2598Publisher
WILEY
DOI: 10.1111/febs.13616
Keywords
apoptosis; caspase; cathepsin; metacaspase; necroptosis; necrosis; NETosis; peptidase; proteolysis; pyroptosis
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Funding
- NIGMS NIH HHS [R01 GM099040] Funding Source: Medline
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This review aims to highlight the proteases required for regulated cell death mechanisms in animals and plants. The aim is to be incisive, and not inclusive of all the animal proteases that have been implicated in various publications. The review also aims to focus on instances when several publications from disparate groups have demonstrated the involvement of an animal protease, and also when there is substantial biochemical, mechanistic and genetic evidence. In doing so, the literature can be culled to a handful of proteases, covering most of the known regulated cell death mechanisms: apoptosis, regulated necrosis, necroptosis, pyroptosis and NETosis in animals. In plants, the literature is younger and not as extensive as for mammals, although the molecular drivers of vacuolar death, necrosis and the hypersensitive response in plants are becoming clearer. Each of these death mechanisms has at least one proteolytic component that plays a major role in controlling the pathway, and sometimes they combine in networks to regulate cell death/survival decision nodes. Some similarities are found among animal and plant cell death proteases but, overall, the pathways that they govern are kingdom-specific with very little overlap.
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