Journal
FEBS JOURNAL
Volume 282, Issue 24, Pages 4672-4678Publisher
WILEY
DOI: 10.1111/febs.13540
Keywords
Keap1-Nrf2 system; mTORC1; p62/Sqstm1; selective autophagy; ubiquitination
Categories
Funding
- Takeda Science Foundation
- [25111006]
- [26253019]
- Grants-in-Aid for Scientific Research [25460400] Funding Source: KAKEN
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p62/SQSTM1 is a stress- inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. In addition, p62/SQSTM1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates. In the present review, we describe the current knowledge about p62 with regard to mammalian target of rapamycin complex 1 activation, the Keap1-Nrf2 pathway and selective autophagy.
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