4.6 Article

Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives

Journal

RSC ADVANCES
Volume 6, Issue 29, Pages 24792-24796

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra00580b

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Funding

  1. National Natural Science Foundation of China [21102179, 21572271]
  2. SRF for ROCS, SEM
  3. National Found for Fostering Talents of Basic Science Grant [J1030830]

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An efficient method for the synthesis of C-1 position acyl substituted pyrazoloquinazoline derivatives via a PBu3-promoted regioselective domino process of sulfonylhydrazones and alkynyl ketones was developed, which may be potentially useful for drug discovery.

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