Journal
FEBS JOURNAL
Volume 282, Issue 6, Pages 1006-1016Publisher
WILEY
DOI: 10.1111/febs.13190
Keywords
activation; activationapoptosis; Bak; Bax; Bcl-2 family; BH3-only proteins; disease; mimetics; oligomerization; therapeutics
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Funding
- Australian Research Council Future Fellowship [FT0990683]
- Australian Research Council [DP110100417]
- Australian Research Council [FT0990683] Funding Source: Australian Research Council
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BH3-only proteins are the sentinels of cellular stress, and their activation commits cells to apoptosis. Since the discovery of the first BH3-only protein BAD almost 20years ago, at least seven more BH3-only proteins have been identified in mammals. They are regulated by a variety of environmental stimuli or by developmental cues, and play a crucial role in cellular homeostasis. Some are considered to be tumor suppressors, and also play a significant role in other pathologies. Their non-apoptotic functions are controversial, but there is broad consensus emerging regarding their role in apoptosis, which may help in designing better therapeutic agents for treating a variety of human diseases.
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