Journal
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
Volume 23, Issue 1, Pages -Publisher
EDP SCIENCES S A
DOI: 10.1051/ocl/2015061
Keywords
AceDoPC (R); acetyl-LysoPC-DHA; blood-brain barrier; carrier
Categories
Funding
- Polaris
- ANR
- Ministry of Research
- LISA Carnot institute
Ask authors/readers for more resources
AceDoPCr (R) is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPCr (R) allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPCr (R) is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPCr (R) prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPCr (R) a promising phospholipid carrier of DHA to the brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available