Journal
FASEB JOURNAL
Volume 29, Issue 12, Pages 5044-5058Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.15-275578
Keywords
ERK1/2; magnesium-L-threonate; PPAR gamma; cerebrospinal fluid; Alzheimer's disease
Categories
Funding
- Natural Science Foundation of China [31300777, 31371091]
- Fundamental Research Funds of China [N142004002, N130120002, N141008001/7, N120820001]
- Liaoning Provincial Talent Support Program [LJQ2013029]
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Alzheimer's disease (AD) is associated with a magnesium ion (Mg2+) deficit in the serum or brain. However, the mechanisms regulating the roles of Mg2+ in the pathologic condition of AD remain unknown. We studied whether brain Mg2+ can decrease beta-amyloid (Ab) deposition and ameliorate the cognitive decline in a model of AD, the APPswe/PS1DE9 transgenic (Tg) mouse. We used a recently developed compound, magnesium-L-threonate (MgT), for a treatment that resulted in enhanced clearance of Ab in an anterior pharynx-defective (APH)-1 alpha/-1 beta-dependent manner. To further explore how MgT treatment inhibits cognitive decline in APP/PS1 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling pathways were investigated. In neurons, ERK1/2 and PPAR gamma signaling pathways were activated by MgT treatment, which in turn suppressed (by >80%) the expression of APH-1 alpha/-1 beta, which is responsible for the deposition of Ab and potentially contributes to the memory deficit that occurs in AD. More important, A beta oligomers in the cerebrospinal fluid (CSF) further promoted the expression of APH-1 alpha/-1 beta (by >2.5-fold), which enhances the gamma-cleavage of APP and Ab deposition during AD progression. These findings provide new insights into the mechanisms of AD progression and are instrumental for developing better strategies to combat the disease.
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