Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 41, Issue 5, Pages 497-505Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-018-1035-1
Keywords
Sanguisorba officinalis L.; Rosaceae; Phenolic; Terpenoids; Anti-inflammatory; Cytokines
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Funding
- Chungnam National University
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Sanguisorba officinalis L. (Rosaceae) is a perennial herbaceous plant and its roots have been used as an important astringent medicine in Eastern Asian countries over many thousand years. In this phytochemical research, 23 compounds (1-23) were isolated from the roots of S. officinalis. Their chemical structures were identified by extensive spectroscopic methods, including 1D and 2D NMR experiments. The anti-inflammatory effects of extracts and isolated compounds were investigated by measuring the production of pro-inflammatory cytokine IL-12 p40, IL-6 and TNF-alpha in LPS-stimulated bone marrow-derived dendritic cell. Compounds 1, 3, 7-8, 11-14 revealed promising anti-inflammatory effects. These results suggested that some phenolic compounds and monoterpenoids from S. officinalis could be potential candidates for anti-inflammatory treatments.
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