Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 647, Issue -, Pages 33-40Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2018.04.008
Keywords
Lutein; Zeaxanthin; Mammalian development; Placenta; Transport; Maternal milk
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Funding
- U.S. National Institute of Health (NIH) [R01HD057493, R01HD057493-02S1, R01HD083331]
- NRI award from USDA-CSREES, Bioactive Food Component for Optimal Health [2006-35200-16580]
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It is now widely accepted that nutrition during critical periods in early development, both pre- and postnatal, may have lifetime consequences in determining health or onset of major diseases in the adult life. Dietary carotenoids have shown beneficial health effects throughout the life cycle due to their potential antioxidant properties, their ability to serves as precursors of vitamin A and to the emerging signaling functions of their metabolites. The non-provitamin A carotenoids lutein and zeaxanthin are emerging as important modulators of infant and child visual and cognitive development, as well as critical effectors in the prevention and treatment of morbidity associated with premature births. This review provides a general overview of lutein and zeaxanthin metabolism in mammalian tissues and highlights the major advancements and remaining gaps in knowledge in regards to their metabolism and health effects during pre- and early post-natal development. Furthering our knowledge in this area of research will impact dietary recommendation and supplementation strategies aimed at sustaining proper fetal and infant growth.
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