Journal
ARCHIV DER PHARMAZIE
Volume 351, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201700314
Keywords
-glycosidase; acetylcholinesterase; butyrylcholinesterase; carbonic anhydrase; phloroglucinol derivatives
Funding
- Turkiye Bilimsel ve Teknolojik Arastirma Kurumu [14Z554]
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A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.
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