Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms17050650
Keywords
mesenchymal stem cell; B-cell; immune regulation; immune suppression; systemic lupus erythematous; graft-versus-host disease; T-cell; plasma cell; cytokine
Funding
- National Natural Science Foundation of China [81471794]
- Chinese High Tech Research & Development (863) Program [SS2013AA020102]
- National Science and Technology Major Project [2012ZX10002004]
Ask authors/readers for more resources
Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available