Journal
MICROBIAL GENOMICS
Volume 2, Issue 5, Pages -Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mgen.0.000060
Keywords
Tuberculosis; transmission; genomic epidemiology; phylogenetics
Categories
Funding
- Engineering and Physical Sciences Research Council [EP/K026003/1]
- Canada Research Chairs program
- Michael Smith Foundation for Health Research
- Engineering and Physical Sciences Research Council [1488403, EP/K026003/1] Funding Source: researchfish
- Medical Research Council [MR/K010174/1, MR/N010760/1, MR/K010174/1B] Funding Source: researchfish
- National Institute for Health Research [HPRU-2012-10080] Funding Source: researchfish
- MRC [MR/N010760/1, MR/K010174/1] Funding Source: UKRI
Ask authors/readers for more resources
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
