Journal
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
Volume 59, Issue 3, Pages 192-196Publisher
KOREAN NEUROSURGICAL SOC
DOI: 10.3340/jkns.2016.59.3.192
Keywords
Cranial sutures; Craniosynostosis; Embryonic development; Growth; Skull
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Understanding the development of a skull deformity requires an understanding of the normal morphogenesis of the cranium. Craniosynostosis is the premature, pathologic ossification of one or more cranial sutures leading to skull deformities. A review of the English medical literature using textbooks and standard search engines was performed to gather information about the prenatal development and growth of the cranial vault of the neurocranium. A process of morphogenic sequencing begins during prenatal development and growth, continues postnatally, and contributes to the basis for the differential manner of growth of cranial vault bones. This improved knowledge might facilitate comprehension of the pathophysiology of craniosynostosis.
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