Journal
EUROPEAN EATING DISORDERS REVIEW
Volume 24, Issue 3, Pages 223-231Publisher
WILEY
DOI: 10.1002/erv.2418
Keywords
binge eating disorder; impulsivity; lisdexamfetamine dimesylate; obsessive-compulsive
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Funding
- Shire Development LLC (Wayne, PA)
- Shire Development LLC
- Complete Healthcare Communications, Inc (CHC)
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In a published 11-week, placebo-controlled trial, 50 and 70mg/d lisdexamfetamine dimesylate (LDX), but not 30mg/d LDX, significantly reduced binge eating days (primary endpoint) in adults with binge eating disorder (BED). This report provides descriptions of LDX effects on secondary endpoints (Binge Eating Scale [BES]; Three-Factor Eating Questionnaire [TFEQ]; Yale-Brown Obsessive Compulsive Scale modified for Binge Eating [Y-BOCS-BE]; and the Barratt Impulsiveness Scale, version 11 [BIS-11]) from that study. Week 11 least squares mean treatment differences favoured all LDX doses over placebo on the BES (p0.03), TFEQ Disinhibition and Hunger subscales (all p<0.05), and Y-BOCS-BE total, obsessive, and compulsive scales (all p0.02) and on BIS-11 total score at 70mg/d LDX (p=0.015) and the TFEQ Cognitive Restraint subscale at 30 and 70mg/d LDX (both p<0.05). These findings indicate that LDX decreased global binge eating severity and obsessive-compulsive and impulsive features of BED in addition to binge eating days. Copyright (c) 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
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