Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 5, Pages 2067-2077Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.002067
Keywords
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Funding
- PolyU Gneral Research Fund [1-ZVHB]
- Joint Supervision Scheme with the Chinese Mainland, Taiwan and Macao Universities [G-SB05]
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An optical fiber sensor integrated microfluidic chip is presented for ultrasensitive detection of glucose. A long-period grating (LPG) inscribed in a small-diameter single-mode fiber (SDSMF) is employed as an optical refractive-index (RI) sensor. With the layer-by-layer (LbL) self-assembly technique, poly (ethylenimine) (PEI) and poly (acrylic acid) (PAA) multilayer film is deposited on the SDSMF-LPG sensor for both supporting and signal enhancement, and then a glucose oxidase (GOD) layer is immobilized on the outer layer for glucose sensing. A microfluidic chip for glucose detection is fabricated after embedding the SDSMF-LPG biosensor into the microchannel of the chip. Experimental results reveal that the SDSMF-LPG biosensor based on such a hybrid sensing film can ultrasensitively detect glucose concentration as low as 1 nM. After integration into the microfluidic chip, the detection range of the sensor is extended from 2 mu M to 10 mu M, and the response time is remarkablely shortened from 6 minutes to 70 seconds. (C) 2016 Optical Society of America
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