Journal
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
Volume 106, Issue 5, Pages 35-36Publisher
SA MEDICAL ASSOC
DOI: 10.7196/SAMJ.2016.v106i5.10710
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The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
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