Journal
EYE
Volume 29, Issue 10, Pages 1270-1284Publisher
SPRINGERNATURE
DOI: 10.1038/eye.2015.158
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Funding
- Fight for Sight [1895/96] Funding Source: researchfish
- National Institute for Health Research [SRF/01/010] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [SRF/01/010] Funding Source: National Institutes of Health Research (NIHR)
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Glaucoma is a neurodegenerative disorder with established relationships with ocular structures such as the retinal nerve fibre layer (RNFL) and the ganglion cell layer (GCL). Ocular imaging techniques such as optical coherence tomography (OCT) allow for quantitative measurement of these structures. OCT has been used in the monitoring of glaucoma, as well as investigating other neurodegenerative conditions such as Alzheimer's disease (AD) and multiple sclerosis (MS). In this review, we highlight the association between these disorders and ocular structures (RNFL and GCL), examining their usefulness as biomarkers of neurodegeneration. The average RNFL thickness loss in patients with AD is 11 mu m, and 7 mu m in MS patients. Most of the studies investigating these changes are cross-sectional. Further longitudinal studies are required to assess sensitivity and specificity of these potential ocular biomarkers to neurodegenerative disease progression.
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