Journal
APPLIED SURFACE SCIENCE
Volume 447, Issue -, Pages 269-278Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2018.03.077
Keywords
Silk fibroin; Poly(ester-urethane) urea elastomer; Nanofiber; Electrospinning; Heart valve tissue engineering
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Funding
- Capacity Building Project of Some Local Colleges and Universities in Shanghai [17030501200]
- National Natural Science Foundation [81501595]
- Youth Foundation of Zhongshan Hospital [2015ZSQN09]
- Talent Training Program Foundation for the Excellent Youth Supported by Zhongshan Hospital [2017ZSYQ24]
- Innovation Fund of Zhongshan Hospital [2017ZSCX05]
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Tissue engineering heart valves (TEHV) are thought to have many advantages in low immunogenicity, good histocompatibility, excellent mechanical properties. In this paper, we reported the fabrication and characterization of a novel composite nanofibrous scaffold consisting of silk fibroin (SF) and poly (ester-urethane) urea (LDI-PEUU) by using electrospinning. Chemical and physical properties of scaffolds were evaluated using scanning electron microscopy, attenuated total reflectance Fourier transform infrared, X-ray diffraction, contact angle measurement, thermogravimetric analysis, biodegradation test and tensile strength analysis. We determined that the composite scaffolds supported the growth of human umbilical vein endothelial cell (HUVEC). The results of cell proliferation and cell morphology indicate that SF/LDI-PEUU nanofibers promoted cell viability, which supporting the application in tissue engineering. All results clarified that SF/LDI-PEUU (40:60) nanofibrous scaffolds meet the required specifications for tissue engineering and could be used as a promising construct for heart valve tissue engineering. (C) 2018 Published by Elsevier B.V.
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