Journal
APPLIED SURFACE SCIENCE
Volume 432, Issue -, Pages 308-316Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2017.04.147
Keywords
Co-electrospinning; Silver sulfadiazine; Antibacterial activity; Bone tissue engineering
Categories
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI14C2241]
- Public welfare & Safety research program through the National Research Foundation of Korea (NRF) - Ministry of Education, Republic of Korea [(NRF-2016R1D1A1B03933644]
- Korea Health Promotion Institute [HI14C2241020017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2016R1D1A1B03933644] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Bone related-bacterial diseases including wound infections and osteomyelitis (OM) still remain a serious problem. In this study, a hybrid co-electrospun membrane consisting of gelatin (GE) and Poly(d, l-lactideco- glycolide) (PLGA) fibrous sheets containing different concentrations (0, 0.1, 0.5, and 1 wt%) of silver sulfadiazine (AgSD) was designed to provide for improved antimicrobial effect and biocompatibility. Well-defined products were characterized by physicochemical analyses. For biological in vitro assessments, mouse osteoblastic MC3T3-E1 cells were cultured on the scaffolds. This test was done in order to assay for cytotoxicity by measuring cell proliferation. Antibacterial activity against gram-negative Pseudomonas aeruginosa (P.aeruginosa), gram-positive Staphylococcus aureus (S. aureus), and Methicillinresistant Staphylococcus aureus (MRSA) was also tested. These biological tests showed that GE/PLGA-AgSD scaffolds had good cell viability, as well as effective antimicrobial activity. These remarkable results suggest that GE/PLGA-AgSD scaffolds possess great potential for the treatment of OM and can find many uses in the field of bone tissue engineering. (C) 2017 Elsevier B.V. All rights reserved.
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