Journal
EYE
Volume 29, Issue 1, Pages 46-64Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2014.240
Keywords
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Categories
Funding
- Action Medical Research
- Ann Allerton Fund
- British Eye Research Foundation
- British Retinitis Pigmentosa Society
- Deutsche Forschungsgemeinschaft
- Dr Hans and Mrs Gertrude Hirsch and Fight for Sight Small Grant Award
- European Economic Community Concerted Action Biomedical and Health Research Programme
- Fight For Sight
- Frost Charitable Trust
- Guide Dogs for the Blind Association
- Iris Fund for Prevention of Blindness
- JP Moulton Charity Trust
- Lady Allerton Research Foundation
- Macular Disease Society
- Macula Society (USA)
- Medical Research Council
- Ministry of Defence
- National Eye Research Council
- NIHR Moorfields Biomedical Research Centre
- National Lottery Charities Board
- Pocklington Foundation
- PPP Healthcare Medical Trust
- Research (Endowments) Committee, UMDS
- Royal College of Surgeons Ophthalmic Research Fund
- Royal National Institute for the Blind
- Royal Society
- Sembal Trust
- South Devon and Cornwall Institution for the Blind
- Special Trustees of St Thomas' Hospital
- United States Air Force
- Wellcome Trust
- Williams Fellowship for Medical and Scientific Research of the University of London
- Worshipful Company of Clothworkers
- Alcon
- Avedro
- Diomed
- Ellex
- IntraLase
- Keeler
- Light Sciences Corporation
- LensX
- Pharmacia
- Retica
- Schwind
- Summit Technology
- TEVA Pharmaceutical Industries Ltd.
- St Thomas's Hospital (King's College London)
- Institute of Ophthalmology (University College London)
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To describe the historical evolution of the role of lasers in effecting therapeutic changes in the four acellular membranes of the eye. Over the past 50 years, iterative developments have been instituted in lasers used for various forms of eye surgery predominately on the basis of data generated in early experiments in the 1960s to determine thresholds for damage and their incorporation in codes of practice for laser safety. The evolutionary steps are described. Excimer laser technology resulted in the generation of the new field of laser refractive surgery with over 40 million individuals now having undergone procedures such as photorefractive keratectomy and LASIK. Developments in lasers used for various forms of retinal surgery have undergone changes involving shorter and shorter pulse durations together with changes in beam energy distribution with implications for potential intervention in AMD prophylactically. Lasers have made a major impact on surgical treatment on all four acellular membranes of the eye but particularly Bowman's membrane in refractive surgery, where it has been demonstrated that it can be removed without significant consequences for eye health or vision.
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