Journal
APPLIED RADIATION AND ISOTOPES
Volume 141, Issue -, Pages 138-148Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2018.06.017
Keywords
Radionuclide concentration; Positron emission tomography (PET); Radiopharmaceutical preparation; Microfluidic radiofluorination; Azeotropic drying free radiofluorination; Anion exchange cartridge; Micro-cartridge
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Funding
- Department of Energy Office of Biological and Environmental Research [DE-SC0005056, DE-SC00001249]
- National Institute on Aging [R21 AG049918]
- National Institute of Mental Health [R44MH097271]
- National Cancer Institute [R21 CA212718, U54 CA151819]
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Concentration of [F-18]fluoride has been mentioned in literature, however, reports have lacked details about system designs, operation, and performance. Here, we describe in detail a compact, fast, fully-automated concentration system based on a micro-sized strong anion exchange cartridge. The concentration of radionuclides enables scaled-up microfluidic synthesis. Our system can also be used to provide highly concentrated [F-18]fluoride with minimal water content. We demonstrate how the concentrator can produce varying concentrations of [F-18]fluoride for the macroscale synthesis of N-boc-5-[F-18]fluoroindole without an azeotropic drying process, while enabling high starting radioactivity. By appropriate choice of solid-phase resin, flow conditions, and eluent solution, we believe this approach can be extended beyond [F-18]fluoride to other radionuclides.
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