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Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves

Journal

PHOTOACOUSTICS
Volume 4, Issue 1, Pages 11-21

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.pacs.2016.01.002

Keywords

Overtone absorption; Photoacoustic microscopy; Photoacoustic tomography; Intravascular photoacoustic; Lipid; Atherosclerosis; Tumor margin

Funding

  1. National Institutes of Health [R01HL125385]
  2. American Heart Association (AHA) National Innovation Award
  3. AHA Scientist Development Grant [14SDG18220010]
  4. Purdue University Center for Cancer Research Jim and Diann Robbers Cancer Research Grant for New Investigators Award
  5. Fortune-Fry Ultrasound Research Fund

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The quantized vibration of chemical bonds provides a way of detecting specific molecules in a complex tissue environment. Unlike pure optical methods, for which imaging depth is limited to a few hundred micrometers by significant optical scattering, photoacoustic detection of vibrational absorption breaks through the optical diffusion limit by taking advantage of diffused photons and weak acoustic scattering. Key features of this method include both high scalability of imaging depth from a few millimeters to a few centimeters and chemical bond selectivity as a novel contrast mechanism for photoacoustic imaging. Its biomedical applications spans detection of white matter loss and regeneration, assessment of breast tumor margins, and diagnosis of vulnerable atherosclerotic plaques. This review provides an overview of the recent advances made in vibration-based photoacoustic imaging and various biomedical applications enabled by this new technology. (C) 2016 The Authors. Published by Elsevier GmbH.

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