Journal
CHEMCATCHEM
Volume 8, Issue 10, Pages 1769-1772Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201600455
Keywords
ball milling; enzyme; kinetic resolution; mechanochemistry; one-pot sequential reaction
Categories
Funding
- RWTH Aachen University from the Distinguished Professorship Program - Excellence Initiative of the German federal government
- RWTH Aachen University from the Distinguished Professorship Program - Excellence Initiative of the German state government
Ask authors/readers for more resources
Mechanosynthesis is a valuable technique, offering attractive alternatives for the preparation of organic, inorganic, and organometallic products. Surprisingly, mechanochemical enzymatic transformations have only scarcely been studied until now. Here, we demonstrate the use of lipase B from Candida antarctica (CALB) in acylative kinetic resolutions of secondary alcohols in mixer and planetary mills. Despite the mechanical stress caused by the high- speed ball milling, the biocatalyst proved highly effective, stable, and, in part, recyclable under the applied mechanochemical conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available