Evaluation of UiO-66 metal organic framework as an effective sorbent for Curcumin's overdose

Metal organic frameworks (MOFs) UiO-66 (UiO stands for University of Oslo) and NH2-UiO-66 were prepared and characterized as sorbent (antidotal agents) for curcumin (CUR) adsorption. The structure of products were characterized by X-ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and N-2 adsorption-desorption measurements. FESEM showed NH2-UiO-66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100nm and uniform size distribution. Adsorption capacities of CUR/MOFs with different mass ratios in the feed were investigated in the present study, and this investigation revealed that when the CUR/MOFs with mass ratio was around 0.4, the absorption capacity of NH2-UiO-66 had tended to maximum. Although, functionalization reduced the specific surface area and free volume, introducing polar amine groups could improve the affinity of NH2-UiO-66 respect to CUR. Kinetic studies showed that the kinetic data are well fitted with the pseudo- second-order model. MTT assay revealed that MOFs at the concentration range of 0-560g/ml had no cytotoxic effect on the Human Foreskin Fibroblast normal cell line (HFF-2). These results suggest that these MOFs could be safe as sorbent for adsorb CUR from the body.