Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 102, Issue 6, Pages 2563-2581Publisher
SPRINGER
DOI: 10.1007/s00253-018-8811-1
Keywords
Phage therapy; Phage-borne polysaccharide depolymerases; Phage lysins; Phage enzymes application in treatment
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Funding
- National Science Centre, Poland [UMO-2016/21/B/NZ6/01157]
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Bacteriophages (phages) are viruses that infect bacteria. The predator-prey interactions are recognized as a potentially effective way to treat infections. Phages, as well as phage-derived proteins, especially enzymes, are intensively studied to become future alternative or supportive antibacterials used alone or in combination with standard antibiotic regimens treatment. There are many publications presenting phage therapy aspects, and some papers focused separately on the application of phage-derived enzymes. In this review, we discuss advantages and limitations of both agents concerning their specificity, mode of action, structural issues, resistance development, pharmacokinetics, product preparation, and interactions with the immune system. Finally, we describe the current regulations for phage-based product application.
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