Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms17060816
Keywords
high resolution mass spectrometry; metabolomics; lipidomics; FTMS; FT-ICR-MS; Orbitrap-MS; metabolomics data analysis
Funding
- Cotton Incorporated
- National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) [5R01AI111962-02]
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Metabolomics, along with other omics approaches, is rapidly becoming one of the major approaches aimed at understanding the organization and dynamics of metabolic networks. Mass spectrometry is often a technique of choice for metabolomics studies due to its high sensitivity, reproducibility and wide dynamic range. High resolution mass spectrometry (HRMS) is a widely practiced technique in analytical and bioanalytical sciences. It offers exceptionally high resolution and the highest degree of structural confirmation. Many metabolomics studies have been conducted using HRMS over the past decade. In this review, we will explore the latest developments in Fourier transform mass spectrometry (FTMS) and Orbitrap based metabolomics technology, its advantages and drawbacks for using in metabolomics and lipidomics studies, and development of novel approaches for processing HRMS data.
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