Journal
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
Volume 1, Issue 2, Pages 109-117Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2016.02.001
Keywords
Synthetic microbial consortium; Single/two/multiple species
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Funding
- National Basic Research Program of China (973 Program) [2014CB745100]
- National Natural Science Foundation of China [21576197]
- Tianjin Research Program of Application Foundation and Advanced Technology [14JCQNJC06700]
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The rapid development of synthetic biology has conferred almost perfect modification on single cells, and provided methodological support for synthesizing microbial consortia, which have a much wider application potential than synthetic single cells. Co-cultivating multiple cell populations with rational strategies based on interacting relationships within natural microbial consortia provides theoretical as well as experimental support for the successful obtaining of synthetic microbial consortia, promoting it into extensive research on both industrial applications in plenty of areas and also better understanding of natural microbial consortia. According to their composition complexity, synthetic microbial consortia are summarized in three aspects in this reviewand are discussed in principles of design and construction, insights and methods for analysis, and applications in energy, healthcare, etc. (c) 2016 The authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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