4.1 Article Data Paper

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog

Journal

DATA IN BRIEF
Volume 7, Issue -, Pages 485-489

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2016.02.076

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Funding

  1. SJCRH Comprehensive Cancer Center Developmental Funds from the National Cancer Institute [P30CA021765]
  2. National Institute of General Medical Science [R01GM101087]
  3. ALSAC of SJCRH

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This data article includes supporting information for the research article entitled The Small GTPase Rapl is a Modulator of Hedgehog Signaling [1] Drosophila wing phenotypes induced by expression of a dominant negative Smoothened (Smo) mutant were cataloged into five distinct classes. Class distributions observed following expression of dominant negative Smo in control and sensitized backgrounds were quantified to serve as references for strength of phenotypic modification. Shifts in class distribution of Hedgehog (Hh) wing phenotypes resulting from introduction of loss-of function alleles of select Ras family G protein genes and the Hh pathway regulators Fused and Suppressor of Fused are shown. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/40).

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