Journal
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 186, Issue 3, Pages 547-562Publisher
HUMANA PRESS INC
DOI: 10.1007/s12010-018-2749-8
Keywords
4-Bromo-1,8-naphthalic anhydride; Quaternized; Naphthalimide; DNA binding; G-Quadruplex DNA selectivity
Funding
- Bulent Ecevit University [2014-72118496-04]
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A new derivate of 4-bromo-1,8-naphthalic anhydride and its quaternized analogue have been prepared and characterized. The interactions of both derivatives with human telomere quadruplex-DNA and ds-DNA have been comparatively studied by UV-visible (UV-Vis), fluorescent intercalator displacement assays, competition dialysis, circular dichroism (CD), agarose gel electrophoresis, and polyacrylamide gel electrophoresis. The results show that both derivatives can stabilize G-quadruplexes DNA, and they show different binding affinities for G-quadruplexes-DNA and ds-DNA. All spectroscopic studies have shown that the derivatives have a modest selectivity for G-quadruplex versus ds-DNA.
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