Journal
TRENDS IN CANCER
Volume 2, Issue 6, Pages 295-304Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2016.05.006
Keywords
-
Categories
Funding
- NIH [CA-198291, CA-67166, CA-197713]
- Silicon Valley Foundation
- Sydney Frank Foundation
- Kimmelman Fund
- Department of Defense Ovarian Cancer Research Academy [OC140611]
- GI-CoRE(GSQ) at Hokkaido University
- CDMRP [794065, OC140611] Funding Source: Federal RePORTER
- Grants-in-Aid for Scientific Research [16K10380] Funding Source: KAKEN
Ask authors/readers for more resources
Hypoxia is a potent microenvironmental factor that promotes tumor metastasis. Recent studies have revealed mechanisms by which hypoxia and activation of hypoxia inducible factor (HIF)-dependent signaling promotes metastasis through the regulation of metabolic reprogramming, the stem cell phenotype, invasion, angiogenesis, immune suppression, the premetastatic niche, intravasation and/or extravasation, and resistance to apoptosis. These discoveries suggest novel paradigms in tumor metastasis and identify new opportunities for therapeutic intervention in the prevention and treatment of metastatic disease. Here, we review the impact of hypoxia and hypoxic signaling pathways in tumor and stromal cells on each step of the metastatic cascade.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available