Journal
ANTIVIRAL RESEARCH
Volume 152, Issue -, Pages 26-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2018.02.003
Keywords
Zika virus; Ebola virus; Broadly active antiviral agents; Virus inactivation; Lipid rafts
Categories
Funding
- DFG [CRC1279, CRC1921, CRC1093]
- Baden-Wurttemberg Stiftung
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Ebola (EBOV) and Zika viruses (ZIKV) are responsible for recent global health threats. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection. This small molecule has previously been shown to inactivate HIV-1 and herpes viruses through a selective interaction with lipid-raft-rich regions in the viral envelope, which results in membrane disruption and loss of infectivity. We found that CLR01 indeed blocked infection of EBOV and ZIKV in a dose-dependent manner. The tweezer inhibited infection of epidemic ZIKV strains in cells derived from the anogenital tract and the central nervous system, and remained antivirally active in the presence of semen, saliva, urine and cerebrospinal fluid. Our findings show that CLR01 is a broad-spectrum inhibitor of enveloped viruses with prospects as a preventative microbicide or antiviral agent.
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