Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 30, Issue 8, Pages 1124-1143Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2018.7527
Keywords
nitric oxide; nitric oxide synthase; cancer; carcinogenesis; metabolism; prognosis
Funding
- Intramural Research Program of the NIH, Cancer and Inflammation Program
- Federal funds from the National Cancer Institute, NIH [HHSN261200800001E]
- NATIONAL CANCER INSTITUTE [ZIASC007281] Funding Source: NIH RePORTER
- Grants-in-Aid for Scientific Research [15KK0323, 15K19833] Funding Source: KAKEN
Ask authors/readers for more resources
Significance: Cancer is a complex disease, which not only involves the tumor but its microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific roles within tumor cells and the microenvironment and determines the rate of cancer progression, therapy efficacy, and patient prognosis. Recent Advances: Key understanding of the processes leading to dysregulated NO flux within the tumor microenvironment over the past decade has provided better understanding of the dichotomous role of NO in cancer and its importance in shaping the immune landscape. It is becoming increasingly evident that nitric oxide synthase 2 (NOS2)-mediated NO/reactive nitrogen oxide species (RNS) are heavily involved in cancer progression and metastasis in different types of tumor. More recent studies have found that NO from NOS2(+) macrophages is required for cancer immunotherapy to be effective. Critical Issues: NO/RNS, unlike other molecules, are unique in their ability to target a plethora of oncogenic pathways during cancer progression. In this review, we subcategorize the different levels of NO produced by cells and shed light on the context-dependent temporal effects on cancer signaling and metabolic shift in the tumor microenvironment. Future Directions: Understanding the source of NO and its spaciotemporal profile within the tumor microenvironment could help improve efficacy of cancer immunotherapies by improving tumor infiltration of immune cells for better tumor clearance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available