Journal
EXPERT REVIEW OF VACCINES
Volume 14, Issue 5, Pages 653-680Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2015.993383
Keywords
genome; malaria; membrane feeding assay; Plasmodium falciparum; transmission-blocking vaccine
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Funding
- Intramural Research Program of the NIAID/NIH
- UK Medical Research Council Career Development Fellow [G1000527]
- Jenner Investigator
- Lister Institute Research Prize Fellow
- Medical Research Council [G1000527] Funding Source: researchfish
- MRC [G1000527] Funding Source: UKRI
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The continued global burden of malaria can in part be attributed to a complex lifecycle, with both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical models of vaccine-induced immunity, antibodies to parasite sexual-stage antigens, ingested in the mosquito blood meal, can inhibit parasite survival in the insect midgut as judged by ex vivo functional studies such as the membrane feeding assay. In an era of renewed political momentum for malaria elimination and eradication campaigns, such observations have fueled support for the development and implementation of so-called transmission-blocking vaccines. While leading candidates are being evaluated using a variety of promising vaccine platforms, the field is also beginning to capitalize on global '-omics' data for the rational genome-based selection and unbiased characterization of parasite and mosquito proteins to expand the candidate list. This review covers the progress and prospects of these recent developments.
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