Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated along-side comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill cm assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and beta-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC50/90 of 0.5/4 mu g/ml and sustained 3-log(10) kill against MDR Escherichia coli, Klebsiella pneumonioe, and Enterobacter spp.