Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 62, Issue 8, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00236-18
Keywords
plazomicin; bactericidal activity; Enterobacteriaceae; bactericidal; multidrug resistance
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Funding
- Achaogen, Inc.
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The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated along-side comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill cm assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and beta-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC50/90 of 0.5/4 mu g/ml and sustained 3-log(10) kill against MDR Escherichia coli, Klebsiella pneumonioe, and Enterobacter spp.
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