Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 62, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00669-18
Keywords
EHR; external evaluation; gentamicin; infant; pharmacokinetics; pediatrics
Categories
Funding
- National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) [T32GM086330]
- National Institute for Child Health and Human Development (NICHD) [K23HD090239]
- U.S. government [HHSN267200700051C]
- Eli Lilly and Company
- Purdue Pharma L.P.
- NICHD [HHSN275201000003I, K23HD091398]
- Duke Clinical and Translational Science Awards [KL2TR001115]
- NIH [1R01-HD076676-01A1]
- National Center for Advancing Translational Sciences of the NIH [UL1TR001117]
- National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272201500006I, HHSN272201300017I]
- Food and Drug Administration (FDA) [1U01FD004858-01]
- Biomedical Advanced Research and Development Authority [HHSO100201300009C]
- Thrasher Research Fund
- CardioDx
- Durata Therapeutics
- FDA [R01FD005101]
- National Heart, Lung, and Blood Institute (NHLBI) [1R34HL124038]
- NICHD Pediatric Trials Network [HHSN267200700051C]
- MRC [MR/M008665/1] Funding Source: UKRI
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Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.
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