Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 62, Issue 5, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00250-18
Keywords
tolerance; persistence; chlorhexidine; imipenem; Acinetobacter; toxin-antitoxin
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Funding
- ISCIII-Deputy General Directorate of Evaluation and Promotion of Research-European Regional Development Fund A Way of Making Europe
- Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI) [RD12/0015/0010, RD16/0016/0001]
- Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC)
- Miguel Servet Research Programme (SERGAS)
- Miguel Servet Research Programme (ISCIII)
- Xunta de Galicia (GAIN, Axencia de Innovacion)
- State Plan for R + D + I (National Plan for Scientific Research, Technological Development and Innovation) [PI13/02390, PI16/01163, PI11-02046]
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The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 beta-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
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