Journal
ANTICANCER RESEARCH
Volume 38, Issue 6, Pages 3689-3697Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.12647
Keywords
Non-small cell lung cancer; elderly; unfit; poor performance status; comorbidity; oral metronomic vinorelbine
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Funding
- Mediterranean Cancer Support and Rehabilitation - Medicare Onlus, Catania, Italy
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Aim: To explore the feasibility and activity of oral metronomic vinorelbine patients with advanced NSCLC not eligible to standard chemotherapy because of old age (>= 70 years), and/or poor Eastern Cooperative Oncology Group performance status (>= 2), and/or extensive brain or bone disease, and/or active comorbidities (>= 2) requiring for pharmacological treatment. Patients and Methods: In a prospective phase II not randomized study, patients with stage IV NSCLC unfit to chemotherapy were treated with oral metronomic vinorelbine at 30 mg fixed dose three times a week until disease progression. Results: Fifty patients were treated, 19 (38%) in the first-line setting. Five patients (11%) experienced a grade 3 toxicity; no grade 4 toxicity occurred. Overall disease control rate was 32%, 44% and 26% in first and subsequent lines, respectively (p=0.39). Median OS and PFS were 7.3 months (95% confidence interval [C1]=4.7-10.0) and 2.7 months (95%CI=2.0-3.4), respectively. Conclusion: These data support the activity and safety of metronomic vinorelbine in a relevant proportion of patients usually excluded from any specific treatment.
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