Journal
ANTICANCER RESEARCH
Volume 38, Issue 3, Pages 1241-1245Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.12345
Keywords
Centrosomal abnormalities; pancreatic cancer; molecular mechanisms; treatment; review
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Funding
- SWElife/Vinnova
- Royal Physiographic Society of Lund
- Magnus Bergvall Foundation
- Tore Nilsson Foundation
- Inga and John Hain Foundation for Medical Research
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The centrosome is the main microtubuleorganizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.
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