Journal
EXPERT REVIEW OF PROTEOMICS
Volume 12, Issue 6, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2015.1099436
Keywords
benign breast disease; BMP6; breast cancer; early diagnosis; erytroferrone; erytropoiesis; erytropoietin; hepcidin; IL-6; inflammation; iron metabolism
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG_13208]
- Italian Ministry of Health
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Objective: Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breast disease or cancer. Methods: Plasma samples from a cohort of 131 patients (47 with benign breast disease and 84 with breast cancer) were subjected to the evaluation of hepcidin, IL-6, EPO and ERFE using SELDI-TOF-MS or immunoassays. Results: An elevated hepcidin was observed in malignant breast tumors compared to benign ones. No correlation was observed between hepcidin and IL-6, EPO or ERFE. Conclusion: Since the study included a cohort of patients (87%) with breast cancers smaller than 2 cm, these results may support our previous evidence about the potential role of hepcidin in breast cancer disease.
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