Journal
EXPERT REVIEW OF PROTEOMICS
Volume 12, Issue 2, Pages 133-146Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2015.1024227
Keywords
cardiovascular disease; mitochondria; protein dynamics; spatial dynamics; temporal dynamics
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Funding
- NHLBI Proteomics Center Award [HHSN268201000035C]
- NIH [R37HL063901, R01HL123060]
- UCLA Laubisch Endowment
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Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.
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