Journal
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13
Volume 13, Issue -, Pages 51-70Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-020117-044030
Keywords
desmosomal cadherins; armadillo proteins; plakin proteins; desmosomal diseases
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Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
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