Journal
ANNUAL REVIEW OF NEUROSCIENCE, VOL 41
Volume 41, Issue -, Pages 255-276Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-080317-061804
Keywords
lysosome; TFEB; autophagy; neurodegenerative storage diseases; neuronal plasticity; lysosomal enhancement
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS079618] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS079618] Funding Source: Medline
Ask authors/readers for more resources
One of the fundamental properties of the cell is the capability to digest and remodel its own components according to metabolic and developmental needs. This is accomplished via the autophagy-lysosome system, a pathway of critical importance in the brain, where it contributes to neuronal plasticity and must protect nonreplaceable neurons from the potentially harmful accumulation of cellular waste. The study of lysosomal biogenesis and function in the context of common and rare neurodegenerative diseases has revealed that a dysfunctional autophagy-lysosome system is the shared nexus where multiple, interconnected pathogenic events take place. The characterization of pathways and mechanisms regulating the lysosomal system and autophagic clearance offers unprecedented opportunities for the development of polyvalent therapeutic strategies based on the enhancement of the autophagy-lysosome pathway to maintain cellular homeostasis and achieve neuroprotection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available